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KMID : 0438219750120030775
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Korea University Medical Journal
1975 Volume.12 No. 3 p.775 ~ p.785
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Effect of Vitamin E on the Hyperbaric Oxygen Toxicity
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李宇爀/Lee, Woo Hyuk
車喆煥/李元暢/Cha, Chul Whan/Lee, Won Chang
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Abstract
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In order to study the preventive, measure of an oxygen toxicity under higher oxygen pressure, rats were given vitamin E and then exposed to at 2 atmospheres of 100% oxygen.
Comparison group which was not administered with vitamin E was also exposed to at 2 atmospheres of 100% oxygen.
Time required to evoke convulsion, correlation between treated dosage of vitamin E and time required to evoke convulsion. half-lethal time and its mean, correlation between treated dosage of vitamin E and fatal time, ratio of lung weight to body weight, and histo-pathological findings of the lungs were carefully examined.
Some interesting results acquired through this study were thus:
1) Average time required to evoke convulsion of rats exposed to at 2 atmospheres of 100% oxygen was 103.72.5 min. in comparison group and 179.09.5 min. or 202.12.7 min. in experimental groups administered with 25 mg or 35mg of vitamin E per day respectively.
Time required to evoke convulsion in experimental groups administered with vitamin E was longer than in comparison group.
Higher correlation between time required to evoke convulsion and treated dosage of vitamin E was shown as r=+0.998 (p<0.01).
2) Average half-lethal times were 210 min. in comparison group and 325 min., 335 min. in groups administered with 25 mg, 35 mg of vitamin E per day respectively. Statistically high correlation between treated dosage of vitamin t and half-lethal time was reported as r=+0.852 (p<0- 0D .
3) Weight ratilo. of lung to. body was significantly higher in experimental group exposed to high .
oxygen tension than control group not exposed to high oxygen tension, `but there was no significant difference among experimental groups.
4) Lur_g damage was more severe in half-lethal group than in servival group during experiment.
Histological changes of the lungs were that of vascular congestion, hemorrhage, pulmonary edema and emphysematous change. And the degree of changes was rather marked in experimental group than in comparison group. There was no difference in the degree of changes by the doses of vitamin E administered in experimental groups.
5) Vitamin E would be an effective agent for the prevention of oxygen poisoning under the high oxygen pressure. Effect of vitamin E administration before exposing to hyperbaric oxygen tension must be pondered to utilize in the "hyperbaric medicine´.
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